Clinical trials methodology: randomization, intent-to-treat, and random-effects regression
نویسندگان
چکیده
منابع مشابه
Exacerbations and intent-to-treat analyses in randomised trials.
In 1998 during a flight from Athens (Greece) to San Francisco (CA, USA), A.M. Hanson, an asthmatic doctor aged 52 yrs, died due to an asthmatic reaction to second-hand cigarette smoke. In 2004, the US Supreme Court ruled that Olympic Airways was to pay the widow of A.M. Hanson US$1.4 million. This successful lawsuit by a passenger against an airline over smoking was unprecedented, and smoking o...
متن کاملA Mixed Model Approach for Intent-to-Treat Analysis in Longitudinal Clinical Trials with Missing Values
Missing values and dropouts are common issues in longitudinal studies in all areas of medicine and public health. Intent-to-treat (ITT) analysis has become a widely accepted method for the analysis of controlled clinical trials. In most controlled clinical trials, some patients do not complete their intended followup according to the protocol for a variety of reasons; this problem generates mis...
متن کاملDynamic randomization and a randomization model for clinical trials data
Randomization models are useful in supporting the validity of linear model analyses applied to data from a clinical trial that employed randomization via permuted blocks. Here, a randomization model for clinical trials data with arbitrary randomization methodology is developed, with treatment effect estimators and standard error estimators valid from a randomization perspective. A central limit...
متن کاملAn Introduction to the Field Trials Methodology
The knowledge related to the methodology of the field trial study as a type of intervention studies, yet for many of our researchers is not fully understood. The aim of the current study was a better understanding of conducting this type of research. Field trial studies are done on healthy individuals and aim to prevent. These types of studies such as clinical trials are performed on both i...
متن کاملRandomization , Rerandomization and Matching in Clinical Trials
Randomization was a key contribution of Sir Ronald Fisher to the conduct of scientific investigations. Along with the protective aspects of randomization, Fisher also noted that the distribution induced by randomization can form the basis of inference. Indeed, in some instances, the randomization test and related procedures seem to be the only tools available for inference. Several authors have...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Depression and Anxiety
سال: 2009
ISSN: 1091-4269,1520-6394
DOI: 10.1002/da.20594